443307-29-7Relevant academic research and scientific papers
One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: A potential prodrug candidate
Li, Ping,Shaw, Barbara Ramsay
, p. 699 - 701 (2007/10/03)
A one-pot synthesis of P-tyrosinyl(P-O)-5′-P-AZT boranophosphate 7 via a phosphoramidite method is described. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by NMR and MS.
Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.
Li, Ping,Shaw, Barbara Ramsay
, p. 2009 - 2012 (2007/10/03)
[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.
