443307-30-0

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 3978-80-1 Boc-Tyr-OH 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 92264-95-4 N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester 

Downstream Products

• 443307-29-7 (S)-3-{4-[[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-(2-cyano-ethoxy)-phosphanyloxy]-phenyl}-2-tert-butoxycarbonylamino-propionic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: A potential prodrug candidate

A one-pot synthesis of P-tyrosinyl(P-O)-5′-P-AZT boranophosphate 7 via a phosphoramidite method is described. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by NMR and MS.

Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.

[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.