443361-70-4Relevant academic research and scientific papers
An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains
Fox, Martin E.,Jackson, Mark,Lennon, Ian C.,McCague, Raymond,Parratt, Julian S.
, p. 50 - 56 (2007/10/03)
The single enantiomer title alcohols, useful as co-side chain precursors for pharmaceutically important prostaglandin analogues were synthesised from the corresponding racemic alcohols by a convenient 4-step sequence. After enzymatic acylation of the alco
Process for the preparation of prostaglandin precursors
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, (2008/06/13)
A propargylic alcohol, enriched in the (R)-enantiomer, has the formula wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This is prepared by the steps of: (a) enantioselective (R)-esterification of the racemic alcohol using any acyl donor and a first enzyme; (b) removal of the untreated (S)-alcohol; and (c) enantioselective hydrolysis of the (R)-ester, using a second enzyme.
