(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Base Information

Chemical Name:(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene
CAS No.:443361-70-4
Molecular Formula:C₁₆H₂₄ClIO₂Si
Molecular Weight:438.808
Hs Code.:

Synonyms:(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Suppliers and Price of (E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Chemical Property:

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Technology Process of (E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

There total 3 articles about (E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-66-8
vinyliodide

: 443361-70-4
(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Guidance literature:

Reference yield:

: (R)-4-(3-chlorophenoxy)-3-(tert-butyldimethylsilyloxy)-1-butyne

: 4-(3-chlorophenoxy)-3-(tert-butyldimethylsilyloxy)-1-butene

: 443361-70-4
(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Guidance literature:: (R)-4-(3-chlorophenoxy)-3-(tert-butyldimethylsilyloxy)-1-butyne; With tert-butylmagnesium chloride; zirconocene dichloride; In diethyl ether; toluene; at 50 - 60 ℃; for 5h;

With iodine; In tetrahydrofuran; toluene; at -40 - 20 ℃; for 0.333333h; Further stages. Title compound not separated from byproducts.;
DOI:10.1002/1615-4169(200201)344:1<50::AID-ADSC50>3.0.CO;2-5

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 443361-70-4
(E)-1-iodo-4-(3-chlorophenoxy)-3(R)-(tert-butyldimethylsilyloxy)-1-butene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99.5 percent / imidazole / dimethylformamide / 2 h / 20 °C

2.1: t-BuMgCl / Cp₂ZrCl₂ / toluene; diethyl ether / 5 h / 50 - 60 °C

2.2: I₂ / toluene; tetrahydrofuran / 0.33 h / -40 - 20 °C

With 1H-imidazole; tert-butylmagnesium chloride; zirconocene dichloride; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1615-4169(200201)344:1<50::AID-ADSC50>3.0.CO;2-5