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2α-deuterioandrost-4-ene-3,17-dione is a synthetic steroid compound that is derived from androst-4-ene-3,17-dione, a naturally occurring steroid hormone. 2α-deuterioandrost-4-ene-3,17-dione is characterized by the presence of a deuterium atom (a stable isotope of hydrogen) at the 2α position, which replaces a regular hydrogen atom. The deuterium substitution can affect the compound's chemical properties and reactivity, potentially altering its metabolic stability and biological activity. This modification is often used in pharmaceutical research to study the metabolism and pharmacokinetics of steroidal compounds, as well as to develop new drugs with improved properties. The compound's structure, with a double bond at the 4 position and ketone groups at the 3 and 17 positions, is typical of androstane derivatives, which are known for their diverse biological effects, including influence on the development and maintenance of male characteristics.

4434-41-7

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4434-41-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4434-41-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,3 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4434-41:
(6*4)+(5*4)+(4*3)+(3*4)+(2*4)+(1*1)=77
77 % 10 = 7
So 4434-41-7 is a valid CAS Registry Number.

4434-41-7Relevant academic research and scientific papers

Syntheses of 2α- and 2β-Deuterio-testosterones and -androst-4-ene-3,17-diones

Holland, Herbert L.,Rao, J. Appa,Chenchaiah, P. Chinna

, p. 2027 - 2032 (2007/10/02)

Testosterone and androst-4-ene-3,17-dione with a deuterium label in the 2α- or 2β-position have been synthesized from a common intermediate, 5α-androst-2-ene-5α,17β-diol.An improved preparation of the latter is described, together with its conversion via epoxidation, reductive epoxide opening, and subsequent oxidation and dehydration to 2β-labelled Δ4-3-oxo steroids.Treatment of the same precursor with labelled diborane leads, by a similar synthetic sequence, to both 2α-, and 2β-labelled Δ4-3-oxo steroids.The stereochemical integrity of the products has been determined by high-field deuterium n.m.r.

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