443642-29-3

Basic information

• Product Name: Lamevudine
• Synonyms: Lamevudine;7-Deaza-2'-C-methyladenosine;(2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol;(2R,3R,4R,5R)-2-(4-aMino-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-5-(hyd;MK-0608;7H-PYRROLO[2,3-D]PYRIMIDIN-4-A;7-(2-C-Methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
• CAS NO: 443642-29-3
• Molecular Formula: C₁₂H₁₆N₄O₄
• Molecular Weight: 280.27984
• EINECS: 200-001-2
• Mol File: 443642-29-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 222 °C(Solv: methanol (67-56-1); acetonitrile (75-05-8))
• Boiling Point: 620.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.75±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.51±0.70(Predicted)
• CAS DataBase Reference: Lamevudine(CAS DataBase Reference)
• NIST Chemistry Reference: Lamevudine(443642-29-3)
• EPA Substance Registry System: Lamevudine(443642-29-3)

Safety Data

• Hazardous Substances Data: 443642-29-3(Hazardous Substances Data)

Usage

Uses

7-Deaza-2''-C-methyladenosine is a hepatitis C virus (HCV) polymerase inhibitor.

Synthetic route

4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine (443642-33-9) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
With ammonia at -78 - 85℃; for 24h;	97%
With ammonia at -78 - 85℃; for 24h;	97%
With ammonia In methanol at 85℃; for 14h;	56%

4-phthalimido-7-[3',5'-di-O-(4-methylbenzoyl)-2'-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine (1053646-61-9) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
With N-butylamine In methanol; toluene at 64℃;	25 g

4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-sulfinic acid (1027082-25-2) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 2: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 3: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 4: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

1,2:5,6-di-O-isopropylidene-3-C-methyl-α-D-allofuranose → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 8 steps 1.1: 10.81 kg / Triton X-405; KOH / toluene; H2O / 20 h / Heating 2.1: 9.02 kg / aq. sulfuric acid / toluene; acetonitrile / 19 °C 3.1: pyridine / acetonitrile / 12 h / 50 - 55 °C 4.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 5.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 5.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 5.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 6.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 7.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 8.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione (741686-49-7) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 2: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

3-O-benzyl-1,2:5,6-di-O-isopropylidene-3-C-methyl-α-D-allofuranose → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 7 steps 1.1: 9.02 kg / aq. sulfuric acid / toluene; acetonitrile / 19 °C 2.1: pyridine / acetonitrile / 12 h / 50 - 55 °C 3.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 4.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 4.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 4.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 5.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 6.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 7.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

1,2-anhydro-2-C-methyl-3,5-di-O-(4-methylbenzoyl)-α-D-ribofuranose (741686-50-0) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 2: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

4-amino-7H-pyrrolo[2,3-d]pyrimidine hydrogen sulfate → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 2: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 3: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

2-C-methyl-3,5-di-O-(4-methylbenzoyl)-D-ribofuranose (943638-20-8) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 2: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 3: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

C30H32O8 → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 4 steps 1.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 1.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 1.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 2.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 3.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 4.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

C33H36O8 → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 5 steps 1.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 2.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 2.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 2.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 3.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 4.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 5.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

4,6-diamino-5-(2,2-diethoxyethyl)pyrimidine-2-thiol potassium salt → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 6 steps 1: 3.95 kg / aq. HCl / 50 °C 2: 99.1 percent / aq. KOH; hydrogen peroxide / 5 - 15 °C 3: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 4: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 5: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 6: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

3-O-benzyl-3-C-methyl-1,2-O-isopropylidene-α-D-allofuranose (55533-86-3, 120615-67-0) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 6 steps 1.1: pyridine / acetonitrile / 12 h / 50 - 55 °C 2.1: aq. HBF4 / acetonitrile / 2 h / 50 - 55 °C 3.1: periodic acid / H2O / 0.5 h / 0 - 5 °C 3.2: diisopropylamine; aq. isopropyl acetate; aq. HCl / methanol / 0 °C 3.3: 4.03 kg / isopropyl acetate; H2 / Pd/C / 24 h / 50 °C / 2327.17 Torr 4.1: 93 percent / MsCl; Et3N / CH2Cl2 / 1.67 h / 30 °C 5.1: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 6.1: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol (98198-24-4) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 5 steps 1: 99.1 percent / aq. KOH; hydrogen peroxide / 5 - 15 °C 2: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 3: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine 4: sodium hydride; N,N-dimethylacetamide / tetrahydrofuran; toluene / 9 h / 50 °C 5: 25 g / n-butylamine / methanol; toluene / 64 °C View Scheme

(3R,4S,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxytetrahydrofuran-3-ol (168427-35-8) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 6 steps 1.1: Dess-Martin periodinane / CH2Cl2 / 72 h / 20 °C 2.1: 16.7 g / diethyl ether / 7 h / -30 - -15 °C 3.1: HBr; AcOH / CH2Cl2 / 4 h / 0 - 20 °C 4.1: NaH / acetonitrile / 4 h / 20 °C 4.2: 5.05 g / acetonitrile / 24 h / 20 °C 5.1: 66 percent / boron trichloride / CH2Cl2 / 5.5 h / -78 - -20 °C 6.1: 56 percent / NH3 / methanol / 14 h / 85 °C View Scheme
Multi-step reaction with 5 steps 1.1: Dess-Martin periodane / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere 2.1: diethyl ether / 7 h / -55 - -15 °C 2.2: 0.5 h / 20 °C / Cooling with ice 3.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / 0 - 20 °C 3.2: 24 h / 20 °C 4.1: boron trichloride / dichloromethane / 5.5 h / -78 - -20 °C 5.1: ammonia / methanol / 14 h / 85 °C / Autoclave View Scheme

3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-erythro-pentafuranos-2-ulose (443642-30-6) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: 16.7 g / diethyl ether / 7 h / -30 - -15 °C 2.1: HBr; AcOH / CH2Cl2 / 4 h / 0 - 20 °C 3.1: NaH / acetonitrile / 4 h / 20 °C 3.2: 5.05 g / acetonitrile / 24 h / 20 °C 4.1: 66 percent / boron trichloride / CH2Cl2 / 5.5 h / -78 - -20 °C 5.1: 56 percent / NH3 / methanol / 14 h / 85 °C View Scheme
Multi-step reaction with 4 steps 1.1: diethyl ether / 7 h / -55 - -15 °C 1.2: 0.5 h / 20 °C / Cooling with ice 2.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / 0 - 20 °C 2.2: 24 h / 20 °C 3.1: boron trichloride / dichloromethane / 5.5 h / -78 - -20 °C 4.1: ammonia / methanol / 14 h / 85 °C / Autoclave View Scheme

(2S,3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-ol (443642-31-7) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: HBr; AcOH / CH2Cl2 / 4 h / 0 - 20 °C 2.1: NaH / acetonitrile / 4 h / 20 °C 2.2: 5.05 g / acetonitrile / 24 h / 20 °C 3.1: 66 percent / boron trichloride / CH2Cl2 / 5.5 h / -78 - -20 °C 4.1: 56 percent / NH3 / methanol / 14 h / 85 °C View Scheme
Multi-step reaction with 3 steps 1.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / 0 - 20 °C 1.2: 24 h / 20 °C 2.1: boron trichloride / dichloromethane / 5.5 h / -78 - -20 °C 3.1: ammonia / methanol / 14 h / 85 °C / Autoclave View Scheme

(3R,4R,5R)-2-Bromo-4-(2,4-dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-methyl-tetrahydro-furan-3-ol (847551-03-5) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: NaH / acetonitrile / 4 h / 20 °C 1.2: 5.05 g / acetonitrile / 24 h / 20 °C 2.1: 66 percent / boron trichloride / CH2Cl2 / 5.5 h / -78 - -20 °C 3.1: 56 percent / NH3 / methanol / 14 h / 85 °C View Scheme

4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine (443642-32-8) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 66 percent / boron trichloride / CH2Cl2 / 5.5 h / -78 - -20 °C 2: 56 percent / NH3 / methanol / 14 h / 85 °C View Scheme
Multi-step reaction with 2 steps 1: boron trichloride / dichloromethane / 5.5 h / -78 - -20 °C 2: ammonia / methanol / 14 h / 85 °C / Autoclave View Scheme

methanolic ammonia + 4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine (443642-33-9) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

2-O-acetyl-3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-ribofuranose (168427-36-9) → 7-deaza-2'-C-methyl-adenosine (443642-29-3)

Conditions

Yield

Multi-step reaction with 6 steps 1.1: methanol; potassium carbonate / 0.75 h / 20 °C 2.1: Dess-Martin periodane / dichloromethane / 73 h / 0 - 20 °C / Inert atmosphere 3.1: diethyl ether / 7 h / -55 - -15 °C 3.2: 0.5 h / 20 °C / Cooling with ice 4.1: hydrogen bromide; acetic acid / dichloromethane / 4 h / 0 - 20 °C 4.2: 24 h / 20 °C 5.1: boron trichloride / dichloromethane / 5.5 h / -78 - -20 °C 6.1: ammonia / methanol / 14 h / 85 °C / Autoclave View Scheme

acetyl chloride (75-36-5) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-methyl-tetrahydro-furan-3-yl ester (887747-99-1)

Conditions	Yield
In acetic acid at 20℃;	94%
In acetic acid at 20℃;	94%

benzoyl chloride (98-88-4) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → C19H20N4O5 (1417563-98-4)

Conditions	Yield
Stage #1: 7-deaza-2'-C-methyl-adenosine With pyridine; chloro-trimethyl-silane for 0.25h; Stage #2: benzoyl chloride at 20℃; for 2h; Stage #3: With ammonia In water for 0.5h;	54%

7-deaza-2'-C-methyl-adenosine (443642-29-3) → 4-amino-5-chloro-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Conditions	Yield
With N-chloro-succinimide In N,N-dimethyl-formamide at 20℃; for 2h;	48%
With N-chloro-succinimide In DMF (N,N-dimethyl-formamide) at 20℃; for 1h;
With N-chloro-succinimide In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	55 mg

phenyl(isopropoxy-L-alaninyl) phosphorochloridate (261909-49-3) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → 7-deaza-2'-C-methyladenosine 5'-O-[phenyl-(isopropoxy-L-alaninyl)]phosphate

Conditions	Yield
Stage #1: 7-deaza-2'-C-methyl-adenosine With pyridine; 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere; Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; Inert atmosphere;	46%

7-deaza-2'-C-methyl-adenosine (443642-29-3) → 4-amino-5-bromo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	43%
With N-Bromosuccinimide In DMF (N,N-dimethyl-formamide) at 0 - 10℃; for 0.5h;
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;	13 mg

phenyl(benzyloxy-L-alaninyl)phosphorochloridate (183370-70-9) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → 7-deaza-2'-C-methyladenosine 5'-O-[phenyl-(benzyloxy-L-alaninyl)]phosphate

Conditions	Yield
Stage #1: 7-deaza-2'-C-methyl-adenosine With pyridine; 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere; Stage #2: phenyl(benzyloxy-L-alaninyl)phosphorochloridate In tetrahydrofuran at 20℃; Inert atmosphere;	40%

acetic anhydride (108-24-7) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → 7-deaza-2'-C-methyl-5'-O-trimethylsilyl-2',3'-O-N6-triacetyladenosine (1402064-60-1)

Conditions	Yield
Stage #1: chloro-trimethyl-silane; 7-deaza-2'-C-methyl-adenosine In pyridine at 20℃; Stage #2: acetic anhydride In pyridine at 20℃; for 3h; Stage #3: With dmap; triethylamine In pyridine at 45 - 50℃;

acetone (67-64-1) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → [(3aR,4R,6R,6aR)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2,6a-trimethyltetrahydrofuro[3,4-d][1,3 ]dioxol-4-yl]methanol (862188-59-8)

Conditions	Yield
With toluene-4-sulfonic acid; orthoformic acid triethyl ester In DMF (N,N-dimethyl-formamide); water at 20 - 80℃; for 3h;

chloro-trimethyl-silane (75-77-4) + acetic anhydride (108-24-7) + 7-deaza-2'-C-methyl-adenosine (443642-29-3) → 7-deaza-2'-C-methyl-5'-O-trimethylsilyl-2',3'-O-N6-triacetyladenosine (1402064-60-1)

Conditions	Yield
Stage #1: chloro-trimethyl-silane; 7-deaza-2'-C-methyl-adenosine In pyridine at 20℃; Stage #2: acetic anhydride In pyridine at 20℃; for 3h; Stage #3: With dmap; triethylamine In pyridine at 45 - 50℃;

Upstream product

• 168427-36-9 2-O-acetyl-3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-ribofuranose 
• 847551-03-5 (3R,4R,5R)-2-Bromo-4-(2,4-dichloro-benzyloxy)-5-(2,4-dichloro-benzyloxymethyl)-3-methyl-tetrahydro-furan-3-ol 
• 443642-31-7 (2S,3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-ol 
• 443642-30-6 3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-erythro-pentafuranos-2-ulose 
• 168427-35-8 (3R,4S,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxytetrahydrofuran-3-ol 
• 98198-24-4 4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-thiol 
• 55533-86-3 3-O-benzyl-3-C-methyl-1,2-O-isopropylidene-α-D-allofuranose 
• 443642-33-9 4-chloro-7-[2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 443642-32-8 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine 
• 943638-20-8 2-C-methyl-3,5-di-O-(4-methylbenzoyl)-D-ribofuranose 
• 769951-32-8 4-amino-7H-pyrrolo[2,3-d]pyrimidine hydrogen sulfate 
• 741686-50-0 1,2-anhydro-3,5-di-O-(4-methylbenzoyl)-2-C-methyl-β-D-ribofuranose 
• 741686-49-7 2-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)isoindoline-1,3-dione 
• 1027082-25-2 4-amino-7H-pyrrolo[2,3-d]pyrimidine-2-sulfinic acid 

Downstream Products

• 443642-46-4 4-amino-5-chloro-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 443642-47-5 4-amino-5-bromo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 

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