443684-50-2

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 75-07-0 acetaldehyde 
• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 487-12-7 isoelemicin 
• 6627-88-9 4-allyl-2,6-dimethoxyphenol 
• 657393-24-3 (1R,2R)-1-(3,4,5-trimethoxyphenyl)propane-1,2-diol 

Downstream Products

• 657393-34-5 (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester 
• 657393-29-8 (2S)-(2,6-dimethoxy-4-propenyl-phenoxy)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-36-7 (2S)-((E)-2-ethoxy-5-propenyl-phenoxy)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-32-3 (2S)-[4-((E)-styryl)-phenoxy]-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-28-7 toluene-4-sulfonic acid (1R)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester 

Relevant academic research and scientific papers

Enantioselective Synthesis of α-Hydroxy Ketones via Benzaldehyde Lyase-Catalyzed C-C Bond Formation Reaction

(R)-Benzoins and (R)-2-hydroxypropiophenone derivatives are formed on a preparative scale by benzaldehyde lyase (BAL)-catalyzed C-C bond formation from aromatic aldehydes and acetaldehyde in aqueous buffer/ DMSO solution with remarkable ease in high chemical yield and high optical purity. The substrate range of this thiamin diphosphate-dependent enzyme was examined with respect to a broad applicability of this benzoin condensation-type reaction in stereoselective synthesis.

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers.

A general asymmetric route to both enantiomers of polysphorin has been developed. The route utilizes polymer-supported reagents, catalysts and scavengers to minimise the need for aqueous work-up and chromatography. This includes application of a method to scavenge 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and a "catch-and-release" procedure to extract the resultant diol following Sharpless asymmetric dihydroxylation. A novel enzymatic selective protection and investigations of a new asymmetric dihydroxylation using microencapsulated osmium tetroxide were also investigated during the course of this study.