657393-24-3

Upstream product

• 20675-95-0 (E)-2,6,-dimethoxy-4-(prop-1-en-1-yl)phenol 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 5438-54-0 1,3-dimethoxy-2-[(prop-2-en-1-yl)oxy]benzene 
• 487-12-7 isoelemicin 

Downstream Products

• 835922-46-8 (R)-1-(3,4,5-trimethoxyphenyl)-2-propanol 
• 657393-34-5 (E)-3-{3-methoxy-4-[(1S)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethoxy]-phenyl}-acrylic acid ethyl ester 
• 657393-29-8 (2S)-(2,6-dimethoxy-4-propenyl-phenoxy)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-36-7 (2S)-((E)-2-ethoxy-5-propenyl-phenoxy)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-32-3 (2S)-[4-((E)-styryl)-phenoxy]-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 
• 657393-28-7 toluene-4-sulfonic acid (1R)-methyl-2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl ester 
• 443684-50-2 (2R)-hydroxy-1-(3,4,5-trimethoxy-phenyl)-propan-1-one 

Relevant academic research and scientific papers

Concise access toward chiral hydroxy phenylpropanoids: formal synthesis of virolongin B; kigelin; kurasoin A; 4-hydroxysattabacin, and actinopolymorphol A

A simple, two step strategy consisting of Sharpless asymmetric dihydroxylation followed by regioselective breaking of [Formula presented] bond is utilized to target key chiral intermediates of natural products virolongin B, kigelin, kurasoin A, 4-hydroxy-sattabacin, and actinopolymorphol A. Derivatives of enantiopure hydroxy phenyl propanoids and α-hydroxy Weinreb amides are synthesized. The reductive cleavage of [Formula presented] bond in a regioselective manner is obtained using Pd/C in methanol.

The synthesis of the anti-malarial natural product polysphorin and analogues using polymer-supported reagents and scavengers.

A general asymmetric route to both enantiomers of polysphorin has been developed. The route utilizes polymer-supported reagents, catalysts and scavengers to minimise the need for aqueous work-up and chromatography. This includes application of a method to scavenge 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and a "catch-and-release" procedure to extract the resultant diol following Sharpless asymmetric dihydroxylation. A novel enzymatic selective protection and investigations of a new asymmetric dihydroxylation using microencapsulated osmium tetroxide were also investigated during the course of this study.