443729-67-7

Basic information

• Product Name: Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-
• Synonyms: Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-;4-Iodo-1-acetyl-7-azaindole
• CAS NO: 443729-67-7
• Molecular Formula: C₉H₇IN₂O
• Molecular Weight: 286.06915
• Mol File: 443729-67-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-(443729-67-7)
• EPA Substance Registry System: Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)-(443729-67-7)

Safety Data

• Hazardous Substances Data: 443729-67-7(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)is used as a potential candidate in medicinal chemistry for its unique molecular structure and potential biological activity. Its pyrrolopyridine ring and iodine atom may offer new avenues for drug discovery and development.
Used in Drug Discovery:
This chemical compound is used in drug discovery as a promising scaffold for the development of new therapeutic agents. Its unique structure may enable the design of novel drugs with specific target interactions and improved pharmacological properties.
Used in Organic Synthesis:
Ethanone, 1-(4-iodo-1H-pyrrolo[2,3-b]pyridin-1-yl)is used as a building block in the synthesis of other complex organic compounds. Its versatile structure allows for further functionalization and modification, enabling the creation of a wide range of molecules with diverse applications.
Used in Research and Investigation:
This chemical compound is utilized in research and investigation to fully understand its properties and potential uses. Further studies are needed to explore its biological activity, stability, and interactions with other molecules, which may lead to new insights and applications in various industries.

Upstream product

• 75-36-5 acetyl chloride 
• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 618446-36-9 1-acetyl-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile 
• 940949-57-5 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-iodo-pyrrolo[2,3-b]pyridine 
• 1287240-29-2 1-[2-deoxy-3,5-di-O-(toluoyl)-β-D-ribofuranosyl]-4-[2,2'-bithien-5-yl]-pyrrolo[2,3-b]pyridine 
• 351439-07-1 methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate 

Relevant articles and documents

NOVEL ARTIFICIAL FLUORESCENT BASES

The present invention relates to novel unnatural fluorescent nucleic acid bases, that is, a purine base, a 2-deazapurine base, and a 2,7-deazapurine base each having a functional group which consists of two or more heterocyclic moieties linked together, at the 6-position thereof (the 6-position of purine ring). The present invention also relates to a compound containing the unnatural base, a derivative thereof, and a nucleic acid containing a nucleotide having the unnatural base. The present invention also relates to a method of preparing the nucleic acid. The unnatural base of the present invention has excellent fluorescence characteristics and also has excellent properties as a universal base.

FUSED HETEROBICYCLIC KINASE INHIBITORS

Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.