443777-10-4Relevant academic research and scientific papers
HETEROCYCLIC INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS
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Page/Page column 27; 28; 35; 44, (2016/08/17)
The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols
Andrade, Leandro H.,Barcellos, Thiago
supporting information; experimental part, p. 3052 - 3055 (2009/12/05)
The first application of enzymes as catalysts to obtain optically pure boron compounds is described. The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied. Aromatic, allylic, and aliphatic secondary alcohols containing a boronate ester or boronic acid group were resolved by lipase from Candida antartica (CALB), and excellent E values (E > 200) and high enantiomeric excesses (up to >99%) of both remaining substrates and acetylated product were obtained.
