864754-38-1

Upstream product

• 108-05-4 vinyl acetate 
• 443777-10-4 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 1173922-38-7 (S)-1-(3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethanol 
• 214360-49-3 1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanone 

Relevant academic research and scientific papers

Stereocomplementary asymmetric bioreduction of boron-containing ketones mediated by alcohol dehydrogenases

Optically active boron-containing alcohols were prepared via the stereoselective reduction of the corresponding carbonyl compounds by alcohol dehydrogenases. Depending on the substrate, both (R)-alcohols and (S)-alcohols were obtained with excellent enantioselectivity (up to >99% ee) employing either ADH-A or LB-ADH.

Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols

The first application of enzymes as catalysts to obtain optically pure boron compounds is described. The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied. Aromatic, allylic, and aliphatic secondary alcohols containing a boronate ester or boronic acid group were resolved by lipase from Candida antartica (CALB), and excellent E values (E > 200) and high enantiomeric excesses (up to >99%) of both remaining substrates and acetylated product were obtained.