44387-06-6

Basic information

• Product Name: methyl hydrazonothiocarbamate
• Synonyms: methyl hydrazonothiocarbamate;S-Methylisothiosemicarbazide;Hydrazinecarboximidothioic acid, methyl ester
• CAS NO: 44387-06-6
• Molecular Formula: C₂H₇N₃S
• Molecular Weight: 105.16
• EINECS: 604-604-1
• Mol File: 44387-06-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 166.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 6.37±0.50(Predicted)
• CAS DataBase Reference: methyl hydrazonothiocarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl hydrazonothiocarbamate(44387-06-6)
• EPA Substance Registry System: methyl hydrazonothiocarbamate(44387-06-6)

Safety Data

• Hazardous Substances Data: 44387-06-6(Hazardous Substances Data)

Upstream product

• 79-19-6 thiosemicarbazide 
• 74-88-4 methyl iodide 

Downstream Products

• 94504-53-7 acetic acid-[4-(S-methyl-isothiosemicarbazonomethyl)-anilide] 
• 91354-24-4 C₁₁H₁₉N₅O 
• 19617-90-4 3,6-diamino-1,2,4,5-tetrazine 
• 81067-82-5 N-benzyl-N'-aminoguanidine 
• 88649-05-2 N¹-4-hydroxysalicylidene-S-methylthiosemicarbazone 
• 59004-62-5 S-Methylthiosemicarbazone of salicyl aldehyde 
• 65746-39-6 N-(4-chlorophenethyl)hydrazinecarboximidamide 
• 69466-52-0 3-methylsulfanyl-5-(thiophen-2-yl)-1,2,4-triazine 
• 1321518-26-6 6-(3,5-dichlorophenyl)-3-(methylthio)-1,2,4-triazin-5-ol 
• 1305075-89-1 C₁₁H₇F₃N₄O₂S 
• 69466-83-7 5-(p-methoxyphenyl)-3-methylsulfanyl-1,2,4-triazine 
• 111628-57-0 5-(2-methoxyphenyl)-3-(methylthio)-1,2,4-triazine 
• 71347-48-3 5-(4-fluorophenyl)-3-(methylthio)-1,2,4-triazine 
• 69467-02-3 5-(3-methoxyphenyl)-3-(methylthio)-1,2,4-triazine 

Relevant articles and documents

Ruthenium(II) carbonyl complexes containing S-methylisothiosemicarbazone based tetradentate ligand: Synthesis, characterization and biological applications

A series of hexa-coordinated ruthenium(II) complexes of the type [Ru(CO)(B)L n ] (n = 1-4; B = PPh3, AsPh3 or Py) have been synthesized by reacting dibasic quadridentate Schiff base ligands H2L n (n = 1-4) with starting complexes [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py). The synthesized complexes were characterized using elemental and various spectral studies including UV-Vis, FT-IR, NMR ( 1H, 13C and 31P) and mass spectroscopy. An octahedral geometry was tentatively proposed for all the complexes based on the spectral data obtained. The experiments on antioxidant activity showed that the ruthenium(II) S-methylisothiosemicarbazone Schiff base complexes exhibited good scavenging activity against various free radicals (DPPH, OH and NO). The in vitro cytotoxicity of these complexes has been evaluated by MTT assay. The results demonstrate that the complexes have good anticancer activities against selected cancer cell line, human breast cancer cell line (MCF-7) and human skin carcinoma cell line (A431). The DNA cleavage studies showed that the complexes have better cleavage of pBR 322 DNA.

N-Hydroxy-N′-aminoguanidines as anti-cancer lead molecule: QSAR, synthesis and biological evaluation

The intrinsic pharmacophore model (rpred2 and rm2 of 0.858 and 0.725) has been developed and used as a query to screen in-house built library based on N-hydroxy-N'-aminoguanidine (HAG) analogs. The pharmacophoric modeled based HITs were synthesized and ev

Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis

Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) produce siderophores with scaffolds of nonribosomal peptide-polyketide origin. Compounds with structural similarities to these siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under iron-limiting conditions mimicking the iron scarcity these pathogens encounter in the host and under standard iron-rich conditions. Several new antimicrobials were identified, including some with increased potency in the iron-limiting condition. Our study illustrates the possibility of screening compound libraries in both iron-rich and iron-limiting conditions to identify antimicrobials that may selectively target iron scarcity-adapted bacteria and highlights the usefulness of building combinatorial libraries of compounds having scaffolds with structural similarities to siderophores to feed into antimicrobial screening programs.