443883-74-7

Upstream product

• 89-82-7 pulegone 
• 75-05-8 acetonitrile 

Downstream Products

• 183620-24-8 [(3R,4R)-3-(2-Furan-3-yl-ethyl)-3,4-dimethyl-cyclohex-1-enyloxy]-trimethyl-silane 
• 183620-22-6 [(3S,4R)-3-(2-Furan-3-yl-ethyl)-4-methyl-cyclohex-1-enyloxy]-trimethyl-silane 
• 183620-23-7 (4R)-(+)-3-[2-(3-furyl)ethyl]-4-methylcyclohex-2-en-1-one 
• 75337-05-2 (+)-(R)-4-methyl-2-cyclohexene-1-one 
• 59805-78-6 (-)-5R,6R-microcionin-2 
• 24302-23-6 (4R)-1-(1-hydroxy-1-methylethyl)-4-methylcyclohexene 

Relevant academic research and scientific papers

(1R,5R)-1-(1-dimethylaminoethyl)-2-isopropylidene-5-methylcyclohexanol as a chiral ligand in the enantioselective addition of diethylzinc to aldehydes

An efficient chiral ligand, (1R,5R)-1-(1-dimethylaminoethyl)-2- isopropylidene-5-methylcyclohexanol, has been developed for the enantioselective addition of diethylzinc to some prochiral aldehydes to afford S-alcohols. The overall conversion rate was 80-98% with excellent enantiomeric excess (79-98%). Georg Thieme Verlag Stuttgart ? New York.

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

The stereoselective synthesis of the spiroketal fragment 4a and its C1″-epimer 4b of the HIV-1 protease inhibitors didemnaketals has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers by intramolecular chiral induction.

The first enantioselective synthesis of (-)-microcionin 2

An approach known to give regiospecific and stereospecific reactions has been applied to the enantioselective synthesis of the natural (-)-microcionin 2 (1), a prototype of trans relationship of the methyl groups on the furanosesquiterpenes.

A Reinvestigation of the Meerwein-Ponndorf-Verley Reduction: A Highly Efficient Variation Using Zirconium Catalysts

A new variation of the Meerwein-Ponndorf-Verley reduction based on mechanistic considerations is presented.Under optimized conditions 1-(4-dimethylaminophenyl)ethanol was used as the reducing alcohol (2-4 equiv.), Zr(O-tBu)4 as the catalyst (0.2 equiv.), and toluene or cyclohexane as the solvent.Aldehydes and ketones (if not extremely sterically hindered) were reduced to the corresponding alcohols at room temperature mostly within 2-4 h in essentially quantitative yield. α,β-Unsaturated carbonyl compounds cleanly react in a 1,2-mode to afford the corresponding allylic alcohols. - Key Words: Reductions / Meerwein-Ponndorf-Verley reaction / Catalysis / Zirconium tetra-tert-butoxide / β-Hydride shift / Kinetics