443886-43-9Relevant academic research and scientific papers
An aqueous, catalyst-free and three-component synthesis of 6-amino-3-(trifluoromethyl)-1,4-dihydro-1-phenyl-4-arylpyrano[2,3-c] pyrazole-5-carbonitriles
Yu, Chenxia,Yao, Changsheng,Li, Tuanjie,Wang, Xiangshan
, p. 1537 - 1544 (2014/05/06)
A concise synthesis of 6-amino-4-aryl-3-(trifluoromethyl)-1,4-dihydro-1- phenylpyrano[2,3-c]pyrazole-5-carbonitriles was performed effectively in aqueous media without catalyst by the reaction of aryl aldehydes, malononitrile, and 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one. This method has the advantages of mild condition, avoidance of the use of catalysts, high yields, and environmentally benign procedure.
Synthesis, cytotoxic, and DNA binding studies of novel fluorinated condensed pyrano pyrazoles
Bhavanarushi,Kanakaiah,Yakaiah,Saddanapu,Addlagatta,Rani, J. Vatsala
, p. 2446 - 2454 (2013/07/26)
One pot solvent-free synthetic method is developed for the synthesis of novel pyrano[2,3-c]pyrazole analogs. Cytotoxicity experiments conducted against a pair of cancerous, non-cancerous lung cell lines, and a cervical cell line is described. These compounds are selectively toxic against cancer cells and not normal cells. Molecular mechanism is established for the mode of DNA binding of these compounds using electrochemical and proton NMR methods.
