443924-77-4Relevant academic research and scientific papers
Ligand-promoted alkylation of C(sp3)-H and C(sp2)-H bonds
Zhu, Ru-Yi,He, Jian,Wang, Xiao-Chen,Yu, Jin-Quan
supporting information, p. 13194 - 13197 (2015/03/30)
9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3) - H and C(sp2) - H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
Synthesis and antiplatelet activity of gemfibrozil chiral analogues
Ammazzalorso, Alessandra,Amoroso, Rosa,Baraldi, Mario,Bettoni, Giancarlo,Braghiroli, Daniela,De Filippis, Barbara,Duranti, Andrea,Moretti, Marco,Tortorella, Paolo,Tricca, Maria Luisa,Vezzalini, Francesca
, p. 817 - 821 (2007/10/03)
The chiral analogues of gemfibrozil 5-(2,5-dimethylphenoxy)-2-methylpentanoic acid and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid were synthesized in optically active form using (S)-4-(1-methylethyl)-2-oxazolidinone as chiral auxiliary. All compounds inhibit human platelet aggregation. From these data, one can surmise that all tested compounds and gemfibrozil act at the platelet level with different mechanism than that of ASA, even if with a different potency.
