443926-87-2Relevant academic research and scientific papers
Synthesis of N,N′-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors
Le Diguarher, Thierry,Ortuno, Jean-Claude,Shanks, David,Guilbaud, Nicolas,Pierre, Alain,Raimbaud, Eric,Fauchere, Jean-Luc,Hickman, John A.,Tucker, Gordon C.,Casara, Patrick J.
, p. 767 - 771 (2007/10/03)
A structure-activity study was performed by synthesis on N,N′-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities.
