74581-23-0 Usage
Uses
Used in Pharmaceutical Industry:
Nortriptyline is utilized as a therapeutic agent for the treatment of depression and other mood disorders. It is prescribed to patients suffering from depressive symptoms, aiming to alleviate their emotional distress and improve their overall quality of life.
Used in Chronic Pain Management:
In addition to its antidepressant properties, nortriptyline is also used as an analgesic for chronic pain conditions such as fibromyalgia and neuropathic pain. It helps in managing the pain by modulating the neurotransmitter levels in the brain, providing relief to patients with persistent pain.
Used in Off-Label Treatments:
Nortriptyline may be employed off-label for certain neurological and gastrointestinal conditions, where its modulation of neurotransmitter levels can potentially offer symptomatic relief or improvement in the condition's management.
Used in Elderly Care with Caution:
While nortriptyline is beneficial for many patients, it is used with caution in elderly individuals due to the potential for increased risk of adverse effects. This cautious approach ensures that the medication is administered safely and effectively in this vulnerable population.
Used in Patients with Heart Disease or Seizure History:
Nortriptyline requires careful administration in patients with a history of heart disease or seizures, as it may exacerbate these conditions. Regular monitoring is recommended to ensure the medication's safe and effective use in such cases.
Check Digit Verification of cas no
The CAS Registry Mumber 74581-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,5,8 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74581-23:
(7*7)+(6*4)+(5*5)+(4*8)+(3*1)+(2*2)+(1*3)=140
140 % 10 = 0
So 74581-23-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O3/c1-17-12(16)14-10-9-5-3-2-4-8(9)6-7-13-11(10)15/h2-5,10H,6-7H2,1H3,(H,13,15)(H,14,16)
74581-23-0Relevant academic research and scientific papers
Synthesis of N,N′-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors
Le Diguarher, Thierry,Ortuno, Jean-Claude,Shanks, David,Guilbaud, Nicolas,Pierre, Alain,Raimbaud, Eric,Fauchere, Jean-Luc,Hickman, John A.,Tucker, Gordon C.,Casara, Patrick J.
, p. 767 - 771 (2007/10/03)
A structure-activity study was performed by synthesis on N,N′-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities.
INTRA VS INTERMOLECULAR AMIDOALKILATION OF AROMATICS
Ishai, D. Ben,Sataty, I.,Peled, N.,Goldshare, R.
, p. 439 - 450 (2007/10/02)
Three tipes of intramolecular amidoalkylation reactions of aromatics, two endotrigonal and one exotrigonal (I, II, III), leading to indolone, N-acylisoquinolines, isoquinolone and benzazepinone derivatives were studied.In the presence of external aromatic nucleophiles competing intermolecular amidoalkylations were observed (1->2, 13->14).The mechanism and the synthetic limitations of the three types of cyclization is discussed.
INTER VS INTRAMOLECULAR AMIDOALKYLATIONS OF AROMATICS - A NEW SYNTHESIS OF OXINDOLES, ISOQUINOLONES AND BENZAZEPINONES
Ben-Ishai, D.,Peled, N.,Sataty, I
, p. 569 - 572 (2007/10/02)
A new synthesis of oxindoles (8) isoquinolones (5) and benzazepinones (10) by the intramolecular amidoalkylation of aromatic amides of bismethoxycarbonylaminoacetic acid (4, 7, 9) is described.
