443974-67-2Relevant academic research and scientific papers
Synthesis of 2-methoxybenzoylhydrazone and evaluation of their antileishmanial activity
Taha, Muhammad,Baharudin, Mohd Syukri,Ismail, Nor Hadiani,Khan, Khalid Mohammed,Jaafar, Faridahanim Mohd,Samreen,Siddiqui, Salman,Choudhary, M. Iqbal
, p. 3463 - 3466 (2013)
Compounds 1-25 showed varying degree of antileishmanial activities with IC50 values ranging between 1.95 and 88.56 μM. Compounds 2, 10, and 11 (IC50 = 3.29 ± 0.07 μM, 1.95 ± 0.04 μM, and 2.49 ± 0.03 μM, respectively) were found to be more active than standard pentamidine (IC50 = 5.09 ± 0.04 μM). Compounds 7 (IC50 = 7.64 ± 0.1 μM), 8 (IC50 = 13.17 ± 0.46 μM), 18 (IC50 = 13.15 ± 0.02 μM), and 24 (IC 50 = 15.65 ± 0.41 μM) exhibited good activities. Compounds 1, 3, 4, 5, 9, 12, 15, 18, and 19 were found to be moderately active. Compounds 13, 14, 16, 17, 20-25 showed weak activities with IC50 values ranging between 57 and 88 μM.
Antioxidant properties of phenolic Schiff bases: Structure-activity relationship and mechanism of action
Anouar, El Hassane,Raweh, Salwa,Bayach, Imene,Taha, Muhammad,Baharudin, Mohd Syukri,Di Meo, Florent,Hasan, Mizaton Hazizul,Adam, Aishah,Ismail, Nor Hadiani,Weber, Jean-Frédéric F.,Trouillas, Patrick
, p. 951 - 964 (2014/01/06)
Phenolic Schiff bases are known for their diverse biological activities and ability to scavenge free radicals. To elucidate (1) the structure-antioxidant activity relationship of a series of thirty synthetic derivatives of 2-methoxybezohydrazide phenolic Schiff bases and (2) to determine the major mechanism involved in free radical scavenging, we used density functional theory calculations (B3P86/6-31+(d,p)) within polarizable continuum model. The results showed the importance of the bond dissociation enthalpies (BDEs) related to the first and second (BDEd) hydrogen atom transfer (intrinsic parameters) for rationalizing the antioxidant activity. In addition to the number of OH groups, the presence of a bromine substituent plays an interesting role in modulating the antioxidant activity. Theoretical thermodynamic and kinetic studies demonstrated that the free radical scavenging by these Schiff bases mainly proceeds through proton-coupled electron transfer rather than sequential proton loss electron transfer, the latter mechanism being only feasible at relatively high pH.
