444-56-4

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 394-56-9 (+/-)-2,2,2-trichloro-1-(4-fluorophenyl)ethanol 
• 108-24-7 acetic anhydride 

Downstream Products

• 57124-76-2 1-(2,2-dichlorovinyl)-4-fluorobenzene 
• 934372-15-3 (Z)-2-chloro-1-(4-fluorophenyl)non-1-ene 
• 934372-12-0 (Z)-2-chloro-1-(4-fluorophenyl)-5-phenylpent-1-ene 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN

We addressed an unexplored application of the Suzuki-Miyaura protocol to the cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN. The use of bisphosphine ligands with a large P-Pd-P bite angle allowed us to synthesize Z-chlorinated internal alkenes in good yields resulting from a selective monocoupling process, a recurrent challenge with 1,1-dichloro-1-alkenes. Moreover, these monochlorinated olefins could be further transformed providing stereospecifically trisubstituted olefins.