57124-76-2

Basic information

• Product Name: Benzene, 1-(2,2-dichloroethenyl)-4-fluoro-
• CAS NO: 57124-76-2
• Molecular Formula: C8H5Cl2F
• Molecular Weight: 191.032
• Mol File: 57124-76-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2,2-dichloroethenyl)-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dichloroethenyl)-4-fluoro-(57124-76-2)
• EPA Substance Registry System: Benzene, 1-(2,2-dichloroethenyl)-4-fluoro-(57124-76-2)

Safety Data

• Hazardous Substances Data: 57124-76-2(Hazardous Substances Data)

Upstream product

• 56-23-5 tetrachloromethane 
• 401514-49-6 [(4-fluorophenyl)methylidene]hydrazine 
• 79-01-6 Trichloroethylene 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 459-57-4 4-fluorobenzaldehyde 
• 75-62-7 Bromotrichloromethane 
• 394-56-9 (+/-)-2,2,2-trichloro-1-(4-fluorophenyl)ethanol 
• 444-56-4 2-acetoxy-1,1,1-trichloro-2-(4-fluoro-phenyl)-ethane 

Downstream Products

• 934372-12-0 (Z)-2-chloro-1-(4-fluorophenyl)-5-phenylpent-1-ene 
• 119346-71-3 ethyl 2-chloro-3-(4-fluorophenyl)prop-2-enoate 
• 1256954-49-0 (Z)-benzyl 2-chloro-3-(4-fluorophenyl)acrylate 
• 1370422-34-6 2-{(4-fluorophenyl)ethynyl}benzoxazole 
• 1645-21-2 2-(4-fluorophenyl)-4H-chromen-4-one 
• 332102-77-9 2-(4-fluorophenyl)-6-methyl-4H-chromen-4-one 
• 132351-71-4 2-(4-fluorophenyl)-7-methoxy-4H-chromen-4-one 
• 934372-15-3 (Z)-2-chloro-1-(4-fluorophenyl)non-1-ene 

Relevant articles and documents

Efficient Multigram Approach to Acetylenes and CF3-ynones Starting from Dichloroalkenes Prepared by Catalytic Olefination Reaction (COR)

A novel approach to terminal acetylenes based on catalytic olefination reaction COR of arylaldehydes to form dichloroalkenes followed by treatment with nBuLi was elaborated. This method is atom economical and displays high yields and effectivity. The corresponding alkynes can be prepared in up to 97 % yield. One pot procedure towards CF3-ynones was elaborated to provide these products in up to 87 % yield starting from dichloroalkenes.

Suzuki-Miyaura cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN

We addressed an unexplored application of the Suzuki-Miyaura protocol to the cross-coupling of 1,1-dichloro-1-alkenes with 9-alkyl-9-BBN. The use of bisphosphine ligands with a large P-Pd-P bite angle allowed us to synthesize Z-chlorinated internal alkenes in good yields resulting from a selective monocoupling process, a recurrent challenge with 1,1-dichloro-1-alkenes. Moreover, these monochlorinated olefins could be further transformed providing stereospecifically trisubstituted olefins.

Conversion of aromatic aldehydes into 1-aryl-2,2-dichloroethenes

A new general one-pot preparative method for the synthesis of 1-aryl(hetaryl)-2,2-dichloroethenes from aldehydes was developed. The method involves successive conversions of the latter into hydrazones followed by treatment with carbon tetrachloride in the