4440-99-7

Basic information

• Product Name: 1,4-diphenyl-2-hydroxy-1,4-butanedione
• Synonyms: 1,4-diphenyl-2-hydroxy-1,4-butanedione
• CAS NO: 4440-99-7
• Molecular Weight: 254.285
• Mol File: 4440-99-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,4-diphenyl-2-hydroxy-1,4-butanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diphenyl-2-hydroxy-1,4-butanedione(4440-99-7)
• EPA Substance Registry System: 1,4-diphenyl-2-hydroxy-1,4-butanedione(4440-99-7)

Safety Data

• Hazardous Substances Data: 4440-99-7(Hazardous Substances Data)

Upstream product

• 4440-98-6 trans-2,3-Epoxy-1,4-diphenyl-1,4-butanedione 
• 64-17-5 ethanol 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 4636-16-2 iodoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 84269-42-1 ((2S,3R)-oxirane-2,3-diyl)bis(phenylmethanone) 
• 4440-98-6 (oxirane-2,3-diyl)bis(phenylmethanone) 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 93845-30-8 2-((4-(tert-butyl)phenyl)sulfinyl)-1-phenylethan-1-one 
• 78146-52-8 phenylglyoxal monohydrate 
• 1074-12-0 phenylglyoxal hydrate 
• 614-20-0 3-oxo-3-phenylpropionic acid 

Downstream Products

• 495-71-6 phenacylacetophenone 
• 891-22-5 3,6-diphenylpyridazine 
• 101736-70-3 acetic acid-(2,5-diphenyl-[3]furyl ester) 
• 107519-54-0 3-chloro-2,5-diphenyl-furan 
• 959-28-4 1,4-diphenylbut-2-ene-1,4-dione 

Relevant articles and documents

A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines

A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.

A novel coupling reaction of α-halo ketones promoted by SmI3/CuI

With SmI3 as the Lewis acid and catalyzed by CuI in DMF, α-haloketones were transformed unexpectedly into α-hydroxy-1,4-diketones in good to moderate yields. The mechanism was probed and a plausible reaction pathway was proposed. DMF was assumed to play a dual role both as a hydroxyl source and as a solvent.

1,3-Dimethyl-2-phenylbenzimidazoline (DMPBI)-acetic acid: An effective reagent system for photoinduced reductive transformation of α,β-epoxy ketones to β-hydroxy ketones

A combination of 1,3-dimethyl-2-phenylbenzimidazoline (DMPBI) and acetic acid has been utilized for photoinduced reductive transformation of α,β-epoxy ketones to β-hydroxy ketones. Study on photoreactions using several proton donors revealed that acetic acid is superior to other proton donors such as HCl, p-TsOH, MeOH, and water. 1,3-Dimethyl-2-phenylbenzimidazolium was produced in the reaction with acetic acid while N-benzoyl-N,N′-dimethyl-o-phenylenediamine was formed in aqueous solvents. When THF solutions containing aryl carbonyl possessing α,β-epoxy ketones and DMPBI and acetic acid were irradiated (λ > 280 nm), β-hydroxy ketones were isolated in good to excellent yields. Photosensitized conditions (λ > 340 nm) were employed for the reactions of alkyl carbonyl possessing α,β-epoxy ketones.