444119-00-0Relevant academic research and scientific papers
Tailored glycopolymers as anticoagulant heparin mimetics
Oh, Young In,Sheng, Gloria J.,Chang, Shuh-Kuen,Hsieh-Wilson, Linda C.
, (2013)
Not to clot: Heparin and its low-molecular-weight derivatives are clinical therapeutics used to treat and prevent blood clots. The synthesis of heparin-based glycopolymers that are potent and potentially safer mimetics of heparin is described. The mimetic
Solid- and solution-phase synthesis of heparin and other glycosaminoglycans
-
, (2008/06/13)
Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides
Modular synthesis of heparin oligosaccharides
Orgueira, Hernan A.,Bartolozzi, Alessandra,Schell, Peter,Litjens, Remy E. J. N.,Palmacci, Emma R.,Seeberger, Peter H.
, p. 140 - 169 (2007/10/03)
A general, modular strategy for the first completely stereoselective synthesis of defined heparin oligosaccharides is described. Six monosaccharide building blocks (four differentially protected glucosamines, one glucuronic and one iduronic acid) were uti
