444120-94-9

Basic information

• Product Name: 2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
• Synonyms: RARECHEM AK ML 0445;AKOS BRN-0198;6-CHLOROPYRIDINE-3-BORONIC ACID PINACOL ESTER;2-CHLORO-5-PYRIDYLBORONIC ACID PINACOL ESTER;2-CHLORO-5-PYRIDINEBORONIC ACID PINACOL ESTER;2-CHLOROPYRIDINE-5-BORONIC ACID, PINACOL ESTER;2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;6-CHLOROPYRIDIN-3-YLBORONIC ACID PINACOL ESTER
• CAS NO: 444120-94-9
• Molecular Formula: C₁₁H₁₅BClNO₂
• Molecular Weight: 239.51
• Mol File: 444120-94-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 86-90 °C
• Boiling Point: 328.3 °C at 760 mmHg
• Flash Point: 152.4 °C
• Appearance: White to light yellow crystal powder
• Density: 1.14 g/cm³
• Vapor Pressure: 0.000364mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 0.17±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE(444120-94-9)
• EPA Substance Registry System: 2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE(444120-94-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36-20/21/22
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 444120-94-9(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

InChI:InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 53939-30-3 5-bromo-2-chloropyridine 
• 69045-79-0 2-choro-5-iodopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 20511-12-0 2-amino-5-iodopyridine 
• 73183-34-3 bis(pinacol)diborane 
• 109-09-1 2-chloropyridine 
• 444120-91-6 6-chloropyridin-3-ylboronic acid 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1269417-00-6 C₁₃H₁₀⁽²⁾H₂ClF₃N₂O 
• 1426414-45-0 (S)-1-(6-chloropyridin-3-yl)-1-phenylethanol 
• 1426414-52-9 (S)-1-phenyl-1-(pyridin-3-yl)ethanol 
• 1415793-90-6 (6-(3-hydroxypyrrolidin-1-yl)pyridin-3-yl)boronic acid 
• 41288-96-4 6-chloropyridine-3-ol 

Relevant articles and documents

Heterocyclic compound and organic electroluminescent device thereof

The invention provides a heterocyclic compound and an organic electroluminescent device thereof. Belong to organic electroluminescence technical field. The heterocyclic compound provided by the invention has relatively high electron mobility and good hole

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

Provided is a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided is a pharmaceutical composition comprising the said compound.

Asymmetric synthesis of 1-heteroaryl-1-arylalkyl tertiary alcohols and 1-pyridyl-1-arylethanes by lithiation-borylation methodology

The synthesis of highly enantioenriched α-heterocyclic tertiary alcohols has been achieved via lithiation-borylation of a configurationally stable lithiated carbamate and heterocyclic pinacol boronic esters followed by oxidation. Protodeboronation of the α-heterocyclic tertiary boronic esters using TBAF·3H2O or CsF gave highly enantioenriched 1-pyridyl-1-arylethanes in high er.