444144-01-8

Basic information

• Product Name: 4-Isoquinolinecarbonitrile, 3-[[2-(2,4-dichlorophenyl)-2-oxoethyl]thio]-5,6,7,8-tetrahydro-1-(2-thienyl )-
• CAS NO: 444144-01-8
• Molecular Formula: C22H16Cl2N2OS2
• Molecular Weight: 459.42
• Mol File: 444144-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Isoquinolinecarbonitrile, 3-[[2-(2,4-dichlorophenyl)-2-oxoethyl]thio]-5,6,7,8-tetrahydro-1-(2-thienyl )-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoquinolinecarbonitrile, 3-[[2-(2,4-dichlorophenyl)-2-oxoethyl]thio]-5,6,7,8-tetrahydro-1-(2-thienyl )-(444144-01-8)
• EPA Substance Registry System: 4-Isoquinolinecarbonitrile, 3-[[2-(2,4-dichlorophenyl)-2-oxoethyl]thio]-5,6,7,8-tetrahydro-1-(2-thienyl )-(444144-01-8)

Safety Data

• Hazardous Substances Data: 444144-01-8(Hazardous Substances Data)

Upstream product

• 129340-06-3 1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinethione 
• 4252-78-2 2,2',4'-trichloroacetophenone 

Relevant articles and documents

Cyclization of nitriles: LIX. Synthesis and properties of 1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinethione derivatives. Molecular and crystal structure of 3-isobutylsulfanyl-1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydroisoquinoline

By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of a series of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It was demonstrated that alkylation of the compound with haloalkanes and their derivatives, in particular with those having electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines. Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]-isoquinoline.