129340-06-3Relevant academic research and scientific papers
Cyclization of nitriles: LIX. Synthesis and properties of 1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydro-3(2H)-isoquinolinethione derivatives. Molecular and crystal structure of 3-isobutylsulfanyl-1-(2-thienyl)-4-cyano-5,6,7,8-tetrahydroisoquinoline
Lozinskii,Chernega,Shelyakin
, p. 1661 - 1665 (2002)
By condensation of 2-(2-thenoyl)-1-cyclohexanone with cyanothioacetamide a new compound of a series of chalcogen-containing isoquinolines with a thiophene fragment in its structure was prepared. It was demonstrated that alkylation of the compound with haloalkanes and their derivatives, in particular with those having electron-withdrawing substituents furnished 3-alkylthio-4-cyano-5,6,7,8-tetrahydroisoquinolines. Some of the latter underwent cyclization into 3-amino-2-R-5-(2-thienyl)-6,7,8,9-tetrahydrothieno[2,3-c]-isoquinoline.
Unexpected Products of the Reaction of Cycloalkylidene(cyano)thioacetamides with Arylmethylenemalononitriles: a Different Novel Synthetic Route to Condensed Pyridine-2(1H)-thiones and Condensed Carbocyclic Nitriles
Elgemeie, Galal Eldin Hamza,Regaila, Hassan Abdla,Shehata, Nadia
, p. 1267 - 1270 (2007/10/02)
A novel synthesis of condensed 3-cyanopyridine-2(1H)-thiones and condensed carbocyclic nitrile derivatives utilizing arylmethylene(cyano)thioacetamides and cycloalkylidenemalononitriles or arylmethylenemalononitriles and cycloalkylidene(cyano)thioacetamides as starting components is described.
