444325-39-7Relevant academic research and scientific papers
Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists
Han, Xiaojun,Michne, Jodi A.,Pin, Sokhom S.,Burris, Kevin D.,Balanda, Lynn A.,Fung, Lawrence K.,Fiedler, Tracey,Browman, Kaitlin E.,Taber, Matthew T.,Zhang, Jie,Dubowchik, Gene M.
, p. 3870 - 3873 (2005)
7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.
