444326-07-2

Upstream product

• 88-05-1 2,4,6-trimethylaniline 
• 139615-94-4 2-(2,4,6-trimethylphenylamino)-3-nitropyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 444325-91-1 3-(2,4,6-trimethyl-phenyl)-3H-imidazo[4,5-b]pyridin-2-ylamine 
• 444325-84-2 N²-mesitylpyridine-2,3-diamine 
• 127-09-3 sodium acetate 

Downstream Products

• 444326-14-1 [2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-yl]-methanol 
• 444326-20-9 3-chloromethyl-2-methyl-8-(2,4,6-trimethyl-phenyl)-8H-1,3a,7,8-tetraaza-cyclopenta[a]indene 

Relevant academic research and scientific papers

An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes

8-Aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes represent a novel series of high-affinity corticotropin-releasing factor-1 receptor (CRF1R) antagonists. Herein we report the synthesis and SAR around the tricyclic core and the anxiolytic activity of an orall