444339-87-1Relevant academic research and scientific papers
Quinolizidine derivatives as ligands for sigma receptors
Sparatore, Anna,Novelli, Federica,Sparatore, Fabio
, p. 1 - 11 (2007/10/03)
A set of 1α/1β-[(4-R-phenyl)ethyl]quinolizidines was synthetized and together with selected intermediates was tested for affinity to sigma-1 receptor. Some compounds displayed good affinity for the relevant receptor, with Ki in the nanomolar range, and good selectivity versus σ2, 5-HT2A and D2 receptor subtypes.
