4445-43-6

Usage

InChI:InChI=1/C13H11NO2/c14-12-8-10(6-7-11(12)13(15)16)9-4-2-1-3-5-9/h1-8H,14H2,(H,15,16)

Upstream product

• 99847-13-9 3-nitrobiphenyl-4-carboxylic acid 
• 135484-83-2 2-amino-4-bromo-benzoic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 99419-89-3 3-nitro-biphenyl-4-carbonitrile 
• 800375-15-9 methyl 3-amino[1,1’-biphenyl]-4-carboxylate 
• 158580-57-5 methyl 4-bromo-2-nitrobenzoate 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 626-01-7 3-Iodoaniline 
• 63608-68-4 3-iodo-isonitrosoacetanilide 
• 20780-77-2 6-iodoisatin 
• 109497-00-9 6-phenylindoline-2,3-dione 

Downstream Products

• 108618-34-4 3-amino-7-phenyl-quinolin-4-ol 
• 100965-88-6 3-nitro-7-phenyl-quinolin-4-ol 

Relevant academic research and scientific papers

ACLY INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

PFKFB3 INHIBITORS AND THEIR USES

This disclosure relates to new phthalimide and isoindolinone derivatives and other PFKFB3 inhibitors for use in the treatment of diseases. The invention further relates to pharmaceutical compositions containing such PFKFB3 inhibitors, methods of preparation thereof, methods for their use as therapeutic agents, and methods of preparation of a medicament for use in therapy, as well as kits and other inventiions comprising such PFKFB3 inhibitors. These PFKFB3 inhibitors are useful for the treatment and prophylaxis of cancer, neurodegenerative diseases, autoimmune diseases, inflammatory disorders, multiple sclerosis, metabolic diseases, inhibition of angiogenesis and other diseases and conditions, where the modulation of PFKFB3 and/or PFKFB4 has beneficial effect as well as neuroprotection.

ANTIBACTERIAL QUINAZOLINE-4(3H)-ONE DERIVATIVES

The invention relates to antibacterial compounds of formula I, wherein R1 is H or halogen; R2 is the group M; R3 is H or halogen; M is MA or MB wherein A is a bond or C≡C; R1A is H or halo

Direct synthesis of new arylanthranilic acids via a Suzuki cross-coupling reaction from iodoisatins

Direct synthesis of new arylanthranilic acids via a Suzuki cross-coupling reaction with iodoisatins as key intermediates is described. A 'one pot' procedure is proposed.

Biaryl substituted alkylboronate esters as thrombin inhibitors

Thrombin is a serine protease that plays an important role in the blood coagulation cascade, and is a target enzyme for new therapeutic agents. Ac- (D)-Phe-Pro-boroArg-OH (DuP 714) was found to be a highly effective thrombin inhibitor. In order to reduce the peptidic nature of DuP 714, we have designed a series of novel biaryl substituted alkylboronate esters as potent thrombin inhibitors. The most potent compounds have subnanomolar affinity for thrombin.