4445-58-3Relevant academic research and scientific papers
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
scheme or table, p. 5162 - 5165 (2010/03/24)
4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
Formation of cyclopent[a]indene and acenaphthylene from allyl esters of biphenyl mono- and di-carboxylic acids and from biphenyl dicarboxylic anhydrides on flash vacuum pyrolysis at 1000-1100°C
Bapat, Jayant B.,Brown, Roger F.C.,Bulmer, Glenn H.,Childs, Trevor,Coulston, Karen J.,Eastwood, Frank W.,Taylor, Dennis K.
, p. 1159 - 1182 (2007/10/03)
Flash vacuum pyrolysis at 1000-1100°C of the allyl esters of the three isomeric biphenylcarboxylic acids, of the allyl esters of the 12 biphenyldicarboxylic acids and of the three biphenyldicarboxylic anhydrides gave pyrolysates which were examined by 1H n.m.r. spectroscopy at temperatures below -50°C. In all cases the spectra showed the presence of cyclopent[a]indene and acenaphthylene together with other products. Possible mechanisms for these ring contraction and cyclization processes are discussed and the results of pyrolyses of [2,3-13C2]biphenyl-2,3-dicarboxylic anhydride, and [3,4-13C2]-and (2-2H1)-biphenyl-3,4-dicarboxylic anhydrides are reported.
Reactive Annulenones: A Comparative Study
Gavina, Francisco,Costero, Ana M.,Gonzalez, Ana M.
, p. 2060 - 2063 (2007/10/02)
Two new and hitherto elusive annulenones, 3-phenylcyclopentadienone and bicycloocta-1(5),3,6-triene-2,8-dione, are reported.Their lifetimes and reactivities have been studied in comparison with those of the related annulenones cyclopentadienone and 4-phenylbicycloocta-1(5),3,6-triene-2,8-dione.The influence of structure and substituents on the stabilities of these species has thereby been established.
SYNTHESIS OF BIPHENYLPOLYCARBOXYLIC ACIDS. I. SYNTHESIS OF BIPHENYL-3,4-DICARBOXYLIC ACID BY LIQUID-PHASE OXIDATION OF 3,4-DIMETHYLBIPHENYL
Koshel', G. N.,Krestinina, T. B.,Shapiro, Yu. E.,Shutova, I. V.,Ogil'ko, M. N.,et al.
, p. 1350 - 1354 (2007/10/02)
During the liquid-phase oxidation of 3,4-dimethylbiphenyl the methyl group at the para positon to the benzene ring is oxidized initially.The final oxidation product is biphenyl-3,4-dicarboxylic acid.
