75884-74-1Relevant academic research and scientific papers
Cu-Catalyzed tandem: N -arylation of phthalhydrazides with cyclic iodoniums to yield dihydrobenzo [c] cinnolines
Kong, Xiangfei,Li, Shiqing,Lv, Hongxu,Xie, Rongrong,Ye, Xiuqing
supporting information, p. 4824 - 4830 (2020/07/13)
Dihydrocinnolines have significant pharmacological properties. Herein, we investigate a Cu-catalyzed tandem N-arylation reaction of phthalhydrazides with cyclic iodonium salts to construct dihydrobenzo[c]cinnoline derivatives. Various iodonium salts, such as symmetrical, unsymmetrical, aryl-aryl, and aryl-heteroaryl ones, could react with phthalhydrazides smoothly and give the title products in moderate to high yields. Moreover, the -NH2 group, which has been diarylated by cyclic iodonium salts to form carbazoles in previous reports, is also well tolerated in this work. This journal is
