444617-44-1

Basic information

• Product Name: 2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE
• Synonyms: 4-TRIFLUOROACETAMIDOMETHYLPIPERIDINE;2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE
• CAS NO: 444617-44-1
• Molecular Formula: C8H13F3N2O
• Molecular Weight: 210.2
• Mol File: 444617-44-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 275.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 11.22±0.46(Predicted)
• CAS DataBase Reference: 2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE(444617-44-1)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE(444617-44-1)

Safety Data

• Hazardous Substances Data: 444617-44-1(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoro-N-piperidin-4-ylmethyl-acetamide is a chemical compound with the molecular formula C10H15F3N2O. It is a fluorinated acetamide derivative with a piperidine ring attached to a trifluoromethyl group. 2,2,2-TRIFLUORO-N-PIPERIDIN-4-YLMETHYL-ACETAMIDE may be used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases. Additionally, it may also be utilized in the field of organic chemistry for the creation of new chemical compounds with unique properties and functionalities. Overall, 2,2,2-Trifluoro-N-piperidin-4-ylmethyl-acetamide has the potential to serve as a valuable intermediate in the production of diverse chemical products.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 7144-05-0 4-Aminomethylpiperidine 

Relevant articles and documents

Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4′-dimethoxytrityl protection in the presence of trityl linkers

An N-protection protocol employing the 4,4′-dimethoxytrityl (Dmt) group in combination with borane reduction of resin-bound polyamides was shown to be an efficient methodology that enables synthesis of novel analogues of natural acylpolyamine toxins. Thus, three philanthotoxins containing polyamine chains with piperidyl and cyclohexyl structural elements, which introduce conformational rigidity, increased lipophilicity, and altered proteolytic properties, were obtained in 39-44% overall yield.