444643-02-1

Basic information

• Product Name: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine
• Synonyms: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine
• CAS NO: 444643-02-1
• Molecular Weight: 293.332
• Mol File: 444643-02-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(444643-02-1)
• EPA Substance Registry System: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(444643-02-1)

Safety Data

• Hazardous Substances Data: 444643-02-1(Hazardous Substances Data)

Upstream product

• 437762-07-7 (S)-1-phenyl-N-{(S)-1-[2-(trifluoromethyl)phenyl]ethyl}ethanamine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 1332827-89-0 C₈H₆O₄*C₁₇H₁₈F₃N 

Downstream Products

• 865815-09-4 (S)-1-(2-(trifluoromethyl)phenyl)ethan-1-amine hydrochloride 
• 1332827-99-2 (S)-2,2,2-trifluoro-N-(1-(2-(trifluoromethyl)phenyl)ethyl)acetamide 
• 127733-39-5 (S)-α-(o-(trifluoromethyl)phenyl)ethylamine 

Relevant articles and documents

Highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring

(Matrix presented) The highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.

Step-efficient access to chiral primary amines

Routes to enantioenriched amines are outlined that employ reductive amination and carbanion addition methods. The strategies require either one or two reaction steps from prochiral carbonyl compounds for the synthesis of the corresponding chiral primary amines. Georg Thieme Verlag Stuttgart New York.

Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines

Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright