444643-11-2

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 98-86-2 acetophenone 
• 66399-30-2 (S)-1-(4-Fluoro-phenyl)-ethylamine 
• 672906-81-9 [1-(4-Fluoro-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 
• 444643-19-0 BrH*C₁₆H₁₈FN 
• 444643-18-9 C₁₆H₁₈FN*ClH 

Downstream Products

• 66399-30-2 (S)-1-(4-Fluoro-phenyl)-ethylamine 
• 672906-83-1 C₁₇H₂₀FN 
• 444643-18-9 C₁₆H₁₈FN*ClH 
• 444643-19-0 BrH*C₁₆H₁₈FN 

Relevant academic research and scientific papers

A Bifunctional MOF Catalyst Containing Metal–Phosphine and Lewis Acidic Active Sites

Post-synthetic modification of the hafnium metal–organic framework MOF-808(Hf) to include triarylphosphine ligands is reported. Sulfonated phenylphosphines are incorporated without oxidation to give a “MOF ligand” that can complex late transition metals such as Ir and Rh to give a bifunctional catalyst containing both metal–phosphine complexes and the Lewis acidic framework hafnium metal sites. The metallated phosphine-bearing MOFs act as fully heterogeneous bifunctional catalysts for tandem reductive amination and hydroaminomethylation reactions.

B(C6F5)3-Catalyzed Asymmetric Reductive Amination of Ketones with Ammonia Borane

The first example of metal-free B(C6F5)3-catalyzed asymmetric reduction amination of ketones with chiral α-methylbenzylamine (α-MBA) using ammonia borane as the reductant is reported. This one-pot method has a broad substrate scope and provides various chiral amines in 81-95% yield with 80-99% de. This protocol was further applied in the total synthesis of cinacalcet.

Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same

An optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine is produced with high optical purity and in an industrially simple and efficient manner by asymmetrically reducing an optically active imine, obtained by dehydration and conde

Practical synthesis of optically active fluorine-substituted α-phenylethylamines by retardation of hydrogenolytic cleavage at benzylic position

High regioselectivity in hydrogenolysis of bis(α-methylbenzyl)amines having a fluorine atom on aromatic ring results from retardation of hydrogenolytic cleavage at benzylic position of fluorine-substituted aromatic ring.

OPTICALLY ACTIVE 1-(FLUORO-,TRIFLUOROMETHYL-OR TRIFLUOROMETHOXY-SUBSTITUTED PHENYL)ALKYLAMINE N-MONOALKYL DERIVATIVES AND PROCESS FOR PRODUCING SAME

An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula [4] is produced by a process including (a) reacting an optically active secondary amine, represented by th