444884-81-5

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 444884-80-4 (S)-2-azido-3-(4-(tert-butoxy)phenyl)propan-1-ol 
• 176502-70-8 (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol 
• 187526-99-4 (9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 

Relevant academic research and scientific papers

Stereoselective synthesis of Ψ[CH2O] pseudodipeptides and conformational analysis of a PheΨ[CH2O]Ala containing analogue of the drug desmopressin

A method for the synthesis of XaaΨ[CH2O]Ala/Gly pseudodipeptides in good yields and excellent diastereoselectivity from azido alcohols and (R)-2-chloropropionic acid or tert-butyl bromoacetate has been developed. Insertion of one of the pseudodipeptide building blocks in the peptide drug desmopressin revealed that methylene either isosteres may have only a minor influence on the secondary structure of peptides.