176502-70-8

Basic information

• Product Name: (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol
• Synonyms: (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol
• CAS NO: 176502-70-8
• Molecular Weight: 223.315
• Mol File: 176502-70-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol(176502-70-8)
• EPA Substance Registry System: (2S)-2-amino-3-(4-tert-butoxyphenyl)propan-1-ol(176502-70-8)

Safety Data

• Hazardous Substances Data: 176502-70-8(Hazardous Substances Data)

Upstream product

• 109953-91-5 [1-(4-tert-butoxy-benzyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester 
• 4727-00-8 O-t-Butyl-L-tyrosine 
• 71989-38-3 Fmoc-Tyr(tBu)-OH 
• 60-18-4 L-tyrosine 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 5545-54-0 N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 5068-29-1 2-benzyloxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionic acid methyl ester 
• 187526-99-4 (9H-fluoren-9-yl)methyl (S)-(1-(4-(tert-butoxy)phenyl)-3-hydroxypropan-2-yl)carbamate 

Downstream Products

• 220237-30-9 N^α-(Dde)-L-tyrosinol(tBu) 
• 109953-91-5 [1-(4-tert-butoxy-benzyl)-2-hydroxy-ethyl]-carbamic acid benzyl ester 
• 1200694-90-1 (S)-2-(4-tert-butoxybenzyl)aziridine 
• 1380230-91-0 (S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-(4-(tert-butoxy)phenyl)propyl)carbamate 
• 869735-99-9 2-[2-azido-3-(4-tert-butoxy-phenyl)-propyl]-isoindole-1,3-dione 
• 220237-32-1 N^α-(Dde)-O-(4-methylphenoxy-allyl acetate)-L-tyrosinol 
• 220237-31-0 N^α-(Dde)-L-tyrosinol 
• 444884-81-5 [2-azido-3-(4-tert-butoxy-phenyl)-propoxy]-acetic acid tert-butyl ester 
• 880489-97-4 ethyl {[(2S)-2-azido-3-(4-tert-butoxyphenyl)propyl]oxy}acetate 
• 880489-98-5 {[(2S)-2-azido-3-(4-tert-butoxyphenyl)propyl]oxy}acetic acid 
• 1262483-67-9 C₂₉H₃₆N₈O₃*ClH 

Relevant articles and documents

Microwave-enhanced solid-phase synthesis of N,N′-linked aliphatic oligoureas and related hybrids

A practical and efficient microwave-assisted solid-phase method for the synthesis of N,N′-linked oligoureas and related amide/urea hybrid oligomers, featuring the use of succinimidyl (2-azido-2-substituted ethyl) carbamate monomers, is reported. The rate enhancement of urea formation under microwave irradiation combined with the mild conditions of the phosphine-based azide reduction makes this approach very effective for routine synthesis of oligoureas and possibly for library production.

Synthesis of novel N-protected β3-amino nitriles: study of their hydrolysis involving a nitrilase-catalyzed step

Several commercially available nitrilases were investigated with regard to their potential to hydrolyze N-protected β3-amino nitriles into their corresponding N-protected β3-amino acids. The biotransformations were obtained in different proportions depending on the nitrilase involved. The best hydrolysis results were achieved for the N-Cbz-β3-amino nitrile from l-alanine using the NIT-107, in a phosphate buffer at 0.05 M. However, no biotransformation into the corresponding acids was observed for the N-sulfonylamide β3-amino nitriles. Two simple and efficient procedures to prepare the β3-amino nitriles from their analogous α-amino acids are described. Thirty four new substances were synthesized and characterized over the course of this work.

Syntheses of amino alcohols and chiral C2-symmetric bisoxazolines derived from O-alkylated R-4-hydroxyphenylglycine and S-tyrosine

Chiral C2-symmetric bisoxazolines 1b-f and 2b,c, derived from 4′-O-alkylated R-4-hydroxyphenylglycine or S-tyrosine, were prepared. As intermediates, a series of chiral amino alcohols possessing substituted phenolic groups was prepared and fully characterized.