444891-22-9Relevant academic research and scientific papers
Optimization and SAR research at the piperazine and phenyl rings of JNJ4796 as new anti-influenza A virus agents, part 1
Wang, Aoyu,Li, Yuhuan,Lv, Kai,Gao, Rongmei,Wang, Apeng,Yan, Haiyan,Qin, Xiaoyu,Xu, Shijie,Ma, Chao,Jiang, Jiandong,Wei, Zengquan,Zhang, Kai,Liu, Mingliang
, (2021/06/15)
JNJ4796, a small molecule fuse inhibitor targeting the conserved stem region of hemagglutinin, effectively neutralized a broad spectrum of group 1 influenza A virus (IAV), and protected mice against lethal and sublethal influenza challenge after oral admi
Privileged structure based ligands for melanocortin receptors - Substituted benzylic piperazine derivatives
Fisher, Matthew J.,Backer, Ryan T.,Collado, Ivan,De Frutos, Oscar,Husain, Saba,Hsiung, Hansen M.,Kuklish, Steve L.,Mateo, Ana I.,Mullaney, Jeffrey T.,Ornstein, Paul L.,Paredes, Cristina Garcia,O'Brian, Thomas P.,Richardson, Timothy I.,Shah, Jikesh,Zgombick, John M.,Briner, Karin
, p. 4973 - 4978 (2007/10/03)
Replacement of the aryl piperazine moiety in compound 1 with a variety of substituted benzylic piperazines (6) yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest
