444902-89-0Relevant articles and documents
Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues
Sun, Haiying,Bapu Reddy, Gaddam,George, Clifford,Meuillet, Emmanuelle J.,Berggren, Margareta,Powis, Garth,Kozikowski, Alan P.
, p. 2835 - 2838 (2002)
Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast