444911-11-9

Upstream product

• 267228-34-2 (S)-2-acetyloxy-3-(4-benzyloxyphenyl)propionic acid 
• 332882-89-0 4-[2,3-bis(tert-butoxycarbonyl)guanidino]butylamine 
• 444911-09-5 (2S,3aS,6R,7aS)-1-{(S)-2-[(S)-2-Acetoxy-3-(4-benzyloxy-phenyl)-propionylamino]-3-phenyl-propionyl}-6-hydroxy-octahydro-indole-2-carboxylic acid methyl ester 
• 444911-13-1 (2S,3aS,6R,7aS)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-(2,2,2-trifluoro-acetoxy)-octahydro-indole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of microcin SF608

The first total synthesis of aquatic peptide microcin SF608 is described. Coupling of L-Hpla with the dipeptide L-Phe-L-Choi followed by coupling with agmatine and a deprotection step gave microcin SF608. In addition, the levorotatory character of L-Hpla (5) was thoroughly established, and the conformational analysis of L-Choi containing peptides 1 and 8-10 was performed using NMR spectroscopy to examine the cis-trans isomer equilibrium of the L-Phe-L-Choi amide bond.