267228-34-2

Upstream product

• 16652-64-5 O-benzyl-S-tyrosine 
• 127-09-3 sodium acetate 
• 60-18-4 L-tyrosine 
• 64-19-7 acetic acid 
• 65733-15-5 (R)-2-amino-3-(4-(benzyloxy)phenyl)propanoic acid 

Downstream Products

• 444911-11-9 C₄₉H₆₆N₆O₁₀ 
• 23508-35-2 (S)-2-hydroxy-3-(4-hydroxy-phenyl)-propionic acid 
• 501368-60-1 (2R,3aR,6R,7aR)-6-Acetoxy-1-{(R)-2-[(S)-2-acetoxy-3-(4-benzyloxy-phenyl)-propionylamino]-4-methyl-pentanoyl}-octahydro-indole-2-carboxylic acid methyl ester 
• 501368-66-7 AcO-L-Hpla(Bn)-D-Leu-3a,7a-diepi-L-Choi(OAc)-OMe 

Relevant academic research and scientific papers

Stereoselective Modification of N-(α-Hydroxyacyl)-glycinesters via Palladium-Catalyzed Allylic Alkylation

N-(α-Hydroxyacyl)-glycinesters can be used as excellent nucleophiles in Pd-catalyzed allylic alkylation. The method allows for the stereoselective introduction of a wide range of side chains, including highly functionalized ones. Both diastereomers can be accessed through variation of the reaction conditions. Furthermore, the use of stannylated carbonates introduces vinylstannane motifs, which are eligible for subsequent C-C coupling reactions.

4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARα/γ agonists. Part I: Synthesis and pharmacological evaluation

Type-2 diabetes (T2D) is a complex metabolic disease characterized by insulin resistance in the liver and peripheral tissues accompanied by a defect in pancreatic β-cell. Since their discovery three subtypes of Peroxisomes Proliferators Activated Receptors were identified namely PPARα, PPARγ and PPARβ/(δ). We were interested in designing novel PPARγ selective agonists and/or dual PPARα/γ agonists. Based on the typical topology of synthetic PPAR agonists, we focused our design approach on 4,4-dimethyl-1,2,3,4-tetrahydroquinoline as novel cyclic tail.

Process for the preparation of new antidiabetic agents

The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where R1represents hydrogen or lower alkyl group and X represents hydrogen or halogen atom.

Synthesis of microcin SF608

The first total synthesis of aquatic peptide microcin SF608 is described. Coupling of L-Hpla with the dipeptide L-Phe-L-Choi followed by coupling with agmatine and a deprotection step gave microcin SF608. In addition, the levorotatory character of L-Hpla (5) was thoroughly established, and the conformational analysis of L-Choi containing peptides 1 and 8-10 was performed using NMR spectroscopy to examine the cis-trans isomer equilibrium of the L-Phe-L-Choi amide bond.