444932-33-6Relevant academic research and scientific papers
Benzothiazole incorporated barbituric acid derivatives: Synthesis and anticonvulsant screening
Siddiqui, Nadeem,Ahsan, Waquar
experimental part, p. 462 - 468 (2009/12/05)
A series of 1-(6-substituted-1,3-benzothiazol-2-yl)-3-(substituted phenyl)hexahydro-2,4,6-pyrimidinetriones 4a-t were synthesized starting from substituted anilines. These compounds contained two active anticonvulsant pharmacophores, benzothiazole and bar
Microwave promoted environmentally benign synthesis of 2- aminobenzothiazoles and their urea derivatives
Li, Zheng,Xiao, Shuxiu,Tian, Guoqiang,Zhu, Anguo,Feng, Xu,Liu, Jing
experimental part, p. 1124 - 1133 (2009/04/06)
2-Aminobenzothiazoles were efficiently synthesized using stable, crystalline tetrabutylammonium tribromide instead of toxic, corrosive liquid bromine under solvent-free and microwave irradiation condition. Furthermore, benzothiazol-2-ylureas were synthesized in good to high yield by reactions of 2-aminobenzothiazoles with N-trichloroacetanilides, which were used as a substitute for toxic, unstable isocyanates, under microwave irradiation condition. This protocol has advantages of no utilization of hazardous chemicals, rapid reaction rate, high yield, and easy work-up procedure. Copyright Taylor & Francis Group, LLC.
