445263-82-1 Usage
General Description
"(6-bromo-imidazo[1,2-a]pyrazin-8-yl)-phenyl-amine" is a chemical compound with the molecular formula C13H9BrN4. It is an organic compound that contains a bromo-imidazo[1,2-a]pyrazin-8-yl and phenyl-amine group. (6-bromo-imidazo[1,2-a]pyrazin-8-yl)-phenyl-amine may have potential applications in medicinal chemistry and pharmaceutical research due to its structural features and potential biological activities. Further studies are needed to explore its potential uses and properties in different fields such as drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 445263-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,5,2,6 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 445263-82:
(8*4)+(7*4)+(6*5)+(5*2)+(4*6)+(3*3)+(2*8)+(1*2)=151
151 % 10 = 1
So 445263-82-1 is a valid CAS Registry Number.
445263-82-1Relevant articles and documents
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells
Bouloc, Nathalie,Large, Jonathan M.,Kosmopoulou, Magda,Sun, Chongbo,Faisal, Amir,Matteucci, Mizio,Reynisson, Jóhannes,Brown, Nathan,Atrash, Butrus,Blagg, Julian,McDonald, Edward,Linardopoulos, Spiros,Bayliss, Richard,Bavetsias, Vassilios
scheme or table, p. 5988 - 5993 (2010/11/02)
Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This led to the design and synthesis of potent Aurora-A inhibitors demonstrating up to 70-fold selectivity in cell-based Aurora kinase pharmacodynamic biomarker assays.
