445298-99-7Relevant articles and documents
Dynamic thermodynamic resolution of N-methylpseudoephedrine α-bromo esters for asymmetric syntheses of α-hydroxy carboxylic acid derivatives
Nam, Jiyoun,Lee, Sang-Kuk,Park, Yong Sun
, p. 2397 - 2401 (2007/10/03)
An example of dynamic thermodynamic resolution in the nucleophilic substitution reactions of α-bromo esters with an oxygen nucleophile is described. Temperature controlled epimerization-substitution sequence provides a practical protocol for the preparation of highly enantioenriched α-hydroxy carboxylic acid derivatives up to 72% yield with 99:1 er.