445303-70-8 Usage
Uses
Used in Pharmaceutical and Agrochemical Industries:
1-Bromo-3-(1,1-difluoro-ethyl)-benzene is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Polymer Production:
1-Bromo-3-(1,1-difluoro-ethyl)-benzene serves as an intermediate in the production of polymers. Its incorporation into polymer structures can enhance properties such as strength, flexibility, and chemical resistance, making the resulting polymers suitable for various applications.
Used in Dye Manufacturing:
1-Bromo-3-(1,1-difluoro-ethyl)-benzene is utilized in the manufacturing of dyes. Its chemical structure contributes to the color and stability of the dyes, which can be used in textiles, inks, and other coloring applications.
Used in Organic Synthesis:
As a reagent for cross-coupling reactions, 1-Bromo-3-(1,1-difluoro-ethyl)-benzene is instrumental in organic synthesis. It aids in the formation of new carbon-carbon bonds, which is crucial for creating complex organic molecules.
Used in Medicinal Chemistry and Drug Discovery:
Due to its potential biological activity, 1-Bromo-3-(1,1-difluoro-ethyl)-benzene is used as a precursor for the preparation of biologically active molecules. Its presence in these molecules can contribute to their efficacy in treating various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 445303-70-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,5,3,0 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 445303-70:
(8*4)+(7*4)+(6*5)+(5*3)+(4*0)+(3*3)+(2*7)+(1*0)=128
128 % 10 = 8
So 445303-70-8 is a valid CAS Registry Number.
445303-70-8Relevant academic research and scientific papers
Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
Ahunovych, Volodymyr,Boretskyi, Andrii,Bugera, Maksym,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Razhyk, Bohdan,Semenov, Sergey,Tarasenko, Karen,Trofymchuk, Serhii
, p. 12181 - 12198 (2021/09/13)
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
Substituted imidazol-pyridazine derivatives
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Page 21, (2010/02/05)
The present invention relates to compounds of formula wherein A is an unsubstituted or substituted cyclic group; and R is hydrogen or lower alkyl; or a pharmaceutically acceptable acid addition salt thereof. These compounds are NMDA NR-2B receptor subtype specific blockers and are useful in the treatment of neurodegeneration, depression and pain.
Imidazole derivatives
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, (2008/06/13)
Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.
