445312-74-3

Basic information

• Product Name: 2-tert-butyl 8a-methyl (8aR)-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate
• Synonyms: 2-tert-butyl 8a-methyl (8aR)-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate;2-(tert-butyl)8a-methyl(R)-6-oxo-4,6,7,8-tetrahydroisoquinoline-2,8a(1H,3H)-dicarboxylate;6-Oxo-4,6,7,8-tetrahydro-3H-isoquinoline-2,8a-dicarboxylic acid 2-tert-butyl ester 8a-methyl ester;(R)-2-tert-butyl 8a-methyl 6-oxo-3,4,6,7,8,8a-hexahydroisoquinoline-2,8a(1H)-dicarboxylate;EOS-61107
• CAS NO: 445312-74-3
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.35752
• Mol File: 445312-74-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 426.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: -2.73±0.40(Predicted)
• CAS DataBase Reference: 2-tert-butyl 8a-methyl (8aR)-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butyl 8a-methyl (8aR)-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate(445312-74-3)
• EPA Substance Registry System: 2-tert-butyl 8a-methyl (8aR)-6-oxo-1,2,3,4,6,7,8,8a-octahydroisoquinoline-2,8a-dicarboxylate(445312-74-3)

Safety Data

• Hazardous Substances Data: 445312-74-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 161491-24-3 methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate 
• 71486-53-8 methyl 4-oxo-3-piperidinecarboxylate hydrochloride 
• 445312-70-9 N-(4-tert-butyloxycarbonyl-2-methoxycarbonyl-4-aza-1-cyclohexenyl)-L-valine diethylamide 
• 445312-71-0 (+)-(S)-1-tert-butyl-3-methyl-4-oxo-3-(3-oxobutyl)piperidine-1,3-dicarboxylate 

Relevant articles and documents

Transformation of an optically active decahydro-6-isoquinolone scaffold: Perfect Felkin-Anh diastereoselectivity

Diastereomerically and enantiomerically pure decahydro-6-isoquinolone derivative 7 (>99% de, 97% ee) was obtained from the Michael addition product 3. Interestingly, aldehyde 7 reacted with a number of different Grignard reagents to give the secondary alc

Copper-catalyzed asymmetric Michael reactions with α-amino acid amides: Synthesis of an optically active piperidine derivative

Quaternary stereocenters are obtained at room temperature in copper-catalyzed asymmetric Michael reactions with α-amino acid amides as chiral auxiliaries. L-Valine diethylamide was applied as a chiral auxiliary, and an optically active piperidine derivati