71486-53-8

Basic information

• Product Name: METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE
• Synonyms: METHYL 4-OXOPIPERIDINE-3-CARBOXYLATE HYDROCHLORIDE;METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE;3-METHOXYCARBONYL-4-PIPERIDONE HYDROCHLORIDE;TIMTEC-BB SBB003611;methyl 4-oxo-3-piperidinecarboxylate hydrochlorid;3-Methoxycarbonyl-4-piperidoneHCl;3-METHOXYCARBONYL-4-PIPERIDONE HYDROCHLORIDE 97+%;3-(Methoxycarbonyl)piperidin-4-one hydrochloride
• CAS NO: 71486-53-8
• Molecular Formula: C₇H₁₁NO₃*ClH
• Molecular Weight: 193.63
• EINECS: 275-526-9
• Product Categories: Building Blocks;C5 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines
• Mol File: 71486-53-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: ~175 °C (dec.)(lit.)
• Boiling Point: 249.4 °C at 760 mmHg
• Flash Point: 104.6 °C
• Appearance: white or cream-colored powder
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Sensitive: Hygroscopic
• Stability: Hygroscopic
• BRN: 4273241
• CAS DataBase Reference: METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE(71486-53-8)
• EPA Substance Registry System: METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE(71486-53-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 71486-53-8(Hazardous Substances Data)

Usage

Chemical Properties

Beige powder

Uses

Methyl 4-oxo-3-piperidinecarboxylate hydrochloride has been used as starting reagent in the synthesis of:nakadomarin Atert-butyl, picolyl and fluorinated analogs of capromorelin

Upstream product

• 793-19-1 bis(2-methoxycarbonylethyl)benzylamine 
• 3939-01-3 methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 

Downstream Products

• 59456-03-0 1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one 
• 127956-05-2 methyl 4-oxo-1-triphenylmethyl-3-piperidinecarboxylate 
• 134201-14-2 2-methyl-5,6,7,8-tetrahydro-3H-pyrido<4,3-d>pyrimidin-4-one 
• 773140-01-5 C₁₃H₁₁ClFN₃O 
• 140176-28-9 1-(carbobenzyloxy)-3-carbomethoxy-3-(phenylselenyl)-4-piperidone 
• 140176-30-3 2-n-butyl-1,3-dimethyl-3-<<(p-toluenesulfonyl)oxy>methyl>-4-piperidone ethylene ketal 
• 135967-39-4 1-(carbobenzyloxy)-3-carbomethoxy-2-<3,8,12,16-tetramethyl-3(E),7(E),8(E),11(E),15-heptadecatrienyl>-4-piperidone 
• 135967-38-3 1-(carbobenzyloxy)-3-carbomethoxy-2-<4,8,12-trimethyl-3(E),7(E),11-tridecatrienyl>-4-piperidone 
• 135967-41-8 2-n-butyl-1-(carbobenzyloxy)-3-carbomethoxy-3-methyl-4-piperidone ethylene ketal 
• 135967-40-7 2-n-butyl-1-(carbobenzyloxy)-3-carbomethoxy-3-methyl-4-piperidone 
• 135967-35-0 2-n-butyl-1-(carbobenzyloxy)-3-carbomethoxy-4-piperidone 
• 135967-34-9 1-(carbobenzyloxy)-3-carbomethoxy-5,6-dihydro-4-pyridone 
• 31633-71-3 methyl 3-methyl-3-carbomethoxy-4-oxo-1-piperidinecarboxylate 
• 189947-44-2 1,4-Dithia-8-aza-spiro[4.5]decane-6,8-dicarboxylic acid 8-benzyl ester 6-methyl ester 

Relevant articles and documents

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control experiment involving a conformationally locked 3-substituted 4-bromo-tert-butyl cyclohexane ring proceeded with essentially complete stereoselectivity.