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Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE is used as a starting reagent for the synthesis of various pharmaceutical compounds, including nakadomycin, atert-butyl, picolyl, and fluorinated analogs of capromorelin. Its unique chemical properties and reactivity make it an essential component in the development of new drugs and therapeutic agents.
Used in the Synthesis of Nakadomarin:
METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE is used as a starting reagent in the synthesis of nakadomycin, a potent antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. Its role in the synthesis process is crucial for the production of this important antibiotic.
Used in the Synthesis of Atert-butyl, Picolyl, and Fluorinated Analogs of Capromorelin:
METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE is also used in the synthesis of atert-butyl, picolyl, and fluorinated analogs of capromorelin, which are modified versions of the original drug with potentially improved pharmacological properties. These analogs may exhibit enhanced efficacy, selectivity, or reduced side effects compared to the parent compound, making them valuable candidates for further research and development in the pharmaceutical industry.

Upstream product

• 3939-01-3 methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 
• 793-19-1 bis(2-methoxycarbonylethyl)benzylamine 

Downstream Products

• 59456-03-0 1,2,3,4-tetrahydro-8,9-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one 
• 127956-05-2 methyl 4-oxo-1-triphenylmethyl-3-piperidinecarboxylate 
• 134201-17-5 2-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one 
• 140176-27-8 1-oxo-1,3-piperidinedicarboxylic acid 1-benzyl ester 3-methyl ester 
• 134201-14-2 2-methyl-5,6,7,8-tetrahydro-3H-pyrido<4,3-d>pyrimidin-4-one 
• 135967-36-1 2-Benzyl-4-oxo-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 135967-37-2 2-[(E)-5-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-pent-3-enyl]-4-oxo-piperidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 
• 773140-01-5 C₁₃H₁₁ClFN₃O 
• 17038-83-4 methyl 1-acetyl-4-oxopiperidine-3-carboxylate 
• 849106-33-8 4-(4-chloro-phenyl)-4-hydroxy-3-methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 193274-00-9 3-(R,S)-Benzyl-4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 1331732-74-1 2-phenyl-5-(pyridin-3-ylmethyl)-1,2,4,5,6,7-hexahydro-3H-pyrazolo[4,3-c]pyridin-3-one 

Relevant academic research and scientific papers

Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation

A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3-sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step. A 9:1 diastereoselectivity was obtained, while a control experiment involving a conformationally locked 3-substituted 4-bromo-tert-butyl cyclohexane ring proceeded with essentially complete stereoselectivity.