445392-12-1Relevant academic research and scientific papers
Copper-catalyzed aerobic oxidative cyclization protocol for the synthesis of quinazolines via amination of C(sp3)-H bonds of methylazaarenes
Liang, En,Wu, Yinrong,Chen, Jiewen,Xiong, Wei,Zhao, Jinwu,Yao, Xingang,Tang, Xiaodong
, (2019)
A new aerobic copper-catalyzed three-component synthesis of azaaryl-substituted quinazolines has been developed, which featured inexpensive methylazaarenes as C1 sources, easily available copper salts as the catalysts and O2 as a sole oxidant. The transformation had very good substrate applicability towards methylazaarenes, and various azaaryl-substituted quinazolines were obtained in moderate to good yields.
TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions
Chan, Chieh-Kai,Lai, Chien-Yu,Wang, Cheng-Chung
, p. 7201 - 7212 (2020/10/02)
In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.
Green synthesis method of polysubstituted quinazoline derivative (by machine translation)
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Paragraph 0032-0045; 0047, (2020/01/04)
The synthesis method disclosed by the invention avoids the use of a complex substrate and. a: strong oxidizing agent, and the synthesis method avoids the use of, a complex substrate and a, strong oxidizing agent, and, the synthesis method, avoids the comp
Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines
Cheung, Wing,Patch, Raymond J.,Player, Mark R.
, p. 2368 - 2371 (2018/05/25)
A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.
Ecofriendly and efficient one-pot procedure for the synthesis of quinazoline derivatives catalyzed by an acidic ionic liquid under aerobic oxidation conditions
Dabiri, Minoo,Salehi, Peyman,Bahramnejad, Mahboobeh
experimental part, p. 3214 - 3225 (2010/12/24)
A three-component condensation reaction between 2-aminobenzophenone derivatives, formaldehyde or aromatic aldehydes, and ammonium acetate efficiently provides substituted quinazolines in a one-pot reaction in the presence of Bronsted acidic ionic liquid, 1-methylimidazolium triflouroacetate ([Hmim]TFA), in conjunction with aerobic oxidation. The ionic liquid was separated from the reaction mixture by simple extraction and was recycled three times without considerable loss in activity. Copyright Taylor & Francis Group, LLC.
