4454-33-5

Usage

Uses

1-Benzyl-3-methoxy-1H-indazole is a redox-active 5-kipoxygenase inhibitor.

Upstream product

• 20187-55-7 bendazac 
• 186581-53-3 diazomethane 
• 2215-63-6 1-benzyl-1,2-dihydro-3H-indazol-3-one 

Relevant academic research and scientific papers

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity

Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and cyclooxygenase (CO) involve a redox cycle, a compound which reduces 5-LPO and CO to their inactive state would give a nonselective inhi