445408-50-4

Upstream product

• 101585-37-9 N-(toluene-4-sulfonyl)-N-p-tolyl-β-alanine 
• 833486-34-3 3-(2-amino-5-methylphenyl)-2-propyn-1-ol 
• 29289-13-2 2-iodo-4-methylaniline 
• 852292-32-1 N-[2-(3-hydroxy-prop-1-ynyl)-4-methyl-phenyl]-4-methyl-benzenesulfonamide 
• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 

Relevant academic research and scientific papers

Superacid-catalyzed tandem Meyer–Schuster rearrangement/intramolecular hydroamination of o-anilinopropargyl alcohols for the synthesis of 2,3-dihydro-4(1H)-quinolones

A TfOH-catalyzed synthesis of 2,3-dihydro-4(1H)-quinolones from o-anilinopropargyl alcohols was developed. Studies of N-protecting groups and substituents in phenyl rings showed that diverse groups could be applied. By controlling the catalyst loading, o-anilinopropargyl alcohols underwent the expected transformation smoothly to produce N-protected or N-deprotected 2,3-dihydro-4 (1H)-quinolones in good yields. This transformation probably involved a tandem Meyer–Schuster rearrangement/intramolecular hydroamination reaction process.