445467-62-9Relevant academic research and scientific papers
SYNPHOS, a new chiral diphosphine ligand: Synthesis, molecular modeling and application in asymmetric hydrogenation
Duprat De Paule, Sébastien,Jeulin, Séverine,Ratovelomanana-Vidal, Virginie,Genêt, Jean-Pierre,Champion, Nicolas,Dellis, Philippe
, p. 823 - 826 (2003)
A new optically active diphosphine ligand, [(5,6),(5′,6′)-bis(ethylenedioxy)biphenyl-2,2′-diyl]bis (diphenylphosphine) (SYNPHOS) has been synthesized and used in ruthenium-catalyzed asymmetric hydrogenation. This new ligand has been compared to other diphosphines (BINAP and MeO-BIPHEP), regarding their dihedral angles and the enantioselectivity in the ruthenium mediated hydrogenation reaction.
Synthesis and Molecular Modeling Studies of SYNPHOS(R), a New, Efficient Diphosphane Ligand For Ruthenium-Catalyzed Asymmetric Hydrogenation
Paule, Sebastien Duprat de,Jeulin, Severine,Ratovelomanana-Vidal, Virginie,Genet, Jean-Pierre,Champion, Nicolas,Dellis, Philippe
, p. 1931 - 1941 (2007/10/03)
A new, optically active, atropisomeric diphosphane ligand, (2,3,2',3'-tetrahydro-5,5'-bi(1,4-benzodioxin)-6,6'-diyl)bis-(diphenylphosphane) (SYNPHOS(R)), has been synthesized, characterized, and used in ruthenium-catalyzed asymmetric hydrogenations. This new ligand has been compared with other atropisomeric diphosphanes (BINAP and MeO-BIPHEP) with respect to their dihedral angles calculated by molecular modeling and the enantioselectivity of their ruthenium-mediated hydrogenation reactions.
SYNPHOS: A new atropisomeric diphosphine ligand. From laboratory-scale synthesis to scale-up development
Duprat De Paule, Sebastien,Jeulin, Severine,Ratovelomanana-Vidal, Virginie,Genet, Jean-Pierre,Champion, Nicolas,Deschaux, Gilles,Dellis, Philippe
, p. 399 - 406 (2013/09/06)
A new optically active diphosphine ligand, [(5,6),(5′,6′)-bis(ethylenedioxy)biphenyl.2,2′-diyl]bis (diphenylphosphine) (SYNPHOS) has been synthesized. Laboratory-scale synthesis and scale-up development of this ligand are described herein. This new atropisomeric diphosphine was also used in ruthenium-catalyzed asymmetric hydrogenation.
